Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers

Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya.

Page No: 36-43

DOI: 10.5281/VEREDAS.2026/V16I5/05

Targeted drug delivery systems have gained significant attention for improving therapeutic specificity and minimizing systemic toxicity in cancer treatment. In the present study, silk-based nanoparticles were developed as carrier systems for the targeted delivery of and Tridax procumbens leaf extract to breast cancer cells in a murine model. Epigallocatechin gallate (EGCG) was conjugated to the nanoparticle surface to function as a targeting ligand, with the aim of enhancing selective interaction with malignant cells. Drug-loaded nanoparticles were prepared using a co-precipitation technique to ensure uniform encapsulation and stability. The therapeutic efficacy of the formulated nanocarriers was evaluated through in vivo assessment of cancerous cells. However, experimental findings indicated no significant inhibition of cell growth. These results suggest that, under the conditions employed in this study, the silk nanoparticle-based delivery system did not enhance the anticancer activity of Tridax procumbens extract against breast cancer cells in mice. The findings highlight the need for further optimization of nanoparticle functionalization, drug loading strategies, and ligand conjugation approaches to improve targeted delivery outcomes in breast cancer therapy.

Citations

APA: Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya. (2026). Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers. DOI: 10.5281/VEREDAS.2026/V16I5/05

AMA: Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya.. Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers. 2026. DOI: 10.5281/VEREDAS.2026/V16I5/05

Chicago: Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya.. "Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers." Published 2026. DOI: 10.5281/VEREDAS.2026/V16I5/05

IEEE: Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya., "Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers," 2026, DOI: 10.5281/VEREDAS.2026/V16I5/05

ISNAD: Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya.. "Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers." DOI: 10.5281/VEREDAS.2026/V16I5/05

MLA: Dr. Deepali Sangale, Miss. Khushbu Oswal, Miss. Sukanya Salunke, Dr. Vitthal Nale, Dr. Sandip Chordiya.. "Masked Therapeutic Activity of Tridax in Silk Fibroin Nanoparticles: A Critical Evaluation of SFNPs as Drug Carriers." 2026, DOI: 10.5281/VEREDAS.2026/V16I5/05